Test Catalog

Test Id : CBC

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Complete Blood Cell Count (CBC) with Differential, Blood

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Overview

Test Catalog

Useful For
Suggests clinical disorders or settings where the test may be helpful

Screening tool to confirm a hematologic disorder, to establish or rule out a diagnosis, to detect an unsuspected hematologic disorder, or to monitor effects of radiation or chemotherapy

Reflex Tests
Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test Id Reporting Name Available Separately Always Performed
DIFFR Morphology Eval (special Smear) No No
PINTP Peripheral Smear Interpretation No No

Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

A morphology evaluation is performed at an additional charge when the automated 5-part differential is invalid or when abnormal results are identified upon microscopic examination.

 

A peripheral blood smear review is performed at an additional charge when pathologist expertise is needed for clinically significant diagnosis.

Method Name
A short description of the method used to perform the test

RF/DC (Radio Frequency/Direct Current) Detection/Hydrodynamic Focusing (DC Detection), Flow Cytometry (Using a Semiconductor Laser)/Sodium Lauryl Sulfate (SLS) Hemoglobin

NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test

CBC with Differential, B

Aliases
Lists additional common names for a test, as an aid in searching

CBC (Complete Blood Count)

Cell Indices

HCT

Hematocrit

Hemoglobin Concentration

Hemoglobin, Blood

Indices

Leukocyte Count

MCHC

MCV

Platelet Count

Platelets

RBC Sizing

Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

A morphology evaluation is performed at an additional charge when the automated 5-part differential is invalid or when abnormal results are identified upon microscopic examination.

 

A peripheral blood smear review is performed at an additional charge when pathologist expertise is needed for clinically significant diagnosis.

Specimen Type
Describes the specimen type validated for testing

Whole Blood EDTA

Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Container/Tube: Lavender top (EDTA)

Specimen Volume: 3 mL

Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.

1.5 mL

Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected

Gross hemolysis Reject
Other Clotted
 

Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen Type Temperature Time Special Container
Whole Blood EDTA Refrigerated (preferred) 48 hours
Ambient 24 hours

Useful For
Suggests clinical disorders or settings where the test may be helpful

Screening tool to confirm a hematologic disorder, to establish or rule out a diagnosis, to detect an unsuspected hematologic disorder, or to monitor effects of radiation or chemotherapy

Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

A morphology evaluation is performed at an additional charge when the automated 5-part differential is invalid or when abnormal results are identified upon microscopic examination.

 

A peripheral blood smear review is performed at an additional charge when pathologist expertise is needed for clinically significant diagnosis.

Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

RBCs, WBCs, and platelets are produced in the bone marrow and released into the peripheral blood. The primary function of the RBC is to deliver oxygen to tissues. WBCs are key components of the immune system. Platelets play a vital role in blood clotting.

 

Mean corpuscular volume (MCV) is a measure of the size of the average RBC. Anemias are characterized as microcytic (MCV <80), macrocytic (MCV >100), or normocytic. The red cell distribution width (RDW) is a measure of the degree of variation in RBC size (anisocytosis). RDW may be helpful in distinguishing between some anemias. For example, iron deficiency anemia is characterized by a high RDW, while thalassemia is characterized by a low RDW.

 

These counts are used as clinical guides in the diagnosis or monitoring of many diseases.

Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

RED BLOOD CELL COUNT (RBC)

Males:

0-14 days: 4.10-5.55 x 10(12)/L

15 days-4 weeks: 3.16-4.63 x 10(12)/L

5 weeks-7 weeks: 3.02-4.22 x 10(12)/L

8 weeks-5 months: 3.43-4.80 x 10(12)/L

6 months-23 months: 4.03-5.07 x 10(12)/L

24 months-35 months: 3.89-4.97 x 10(12)/L

3-5 years: 4.00-5.10 x 10(12)/L

6-10 years: 4.10-5.20 x 10(12)/L

11-14 years: 4.20-5.30 x 10(12)/L

15-17 years: 4.30-5.70 x 10(12)/L

Adults: 4.35-5.65 x 10(12)/L

 

Females:

0-14 days: 4.12-5.74 x 10(12)/L

15 days-4 weeks: 3.32-4.80 x 10(12)/L

5 weeks-7 weeks: 2.93-3.87 x 10(12)/L

8 weeks-5 months: 3.45-4.75 x 10(12)/L

6 months-23 months: 3.97-5.01 x 10(12)/L

24 months-35 months: 3.84-4.92 x 10(12)/L

3-5 years: 4.00-5.10 x 10(12)/L

6-10 years: 4.10-5.20 x 10(12)/L

11-14 years: 4.10-5.10 x 10(12)/L

15-17 years: 3.80-5.00 x 10(12)/L

Adults: 3.92-5.13 x 10(12)/L

 

HEMOGLOBIN

Males:

0-14 days: 13.9-19.1 g/dL

15 days-4 weeks: 10.0-15.3 g/dL

5 weeks-7 weeks: 8.9-12.7 g/dL

8 weeks-5 months: 9.6-12.4 g/dL

6 months-23 months: 10.1-12.5 g/dL

24 months-35 months: 10.2-12.7 g/dL

3-5 years: 11.4-14.3 g/dL

6-8 years: 11.5-14.3 g/dL

9-10 years: 11.8-14.7 g/dL

11-14 years: 12.4-15.7 g/dL

15-17 years: 13.3-16.9 g/dL

Adults: 13.2-16.6 g/dL

 

Females:

0-14 days: 13.4-20.0 g/dL

15 days-4 weeks: 10.8-14.6 g/dL

5 weeks-7 weeks: 9.2-11.4 g/dL

8 weeks-5 months: 9.9-12.4 g/dL

6 months-35 months: 10.2-12.7 g/dL

3-5 years: 11.4-14.3 g/dL

6-8 years: 11.5-14.3 g/dL

9-10 years: 11.8-14.7 g/dL

11-17 years: 11.9-14.8 g/dL

Adults: 11.6-15.0 g/dL

 

HEMATOCRIT

Males:

0-14 days: 39.8-53.6%

15 days-4 weeks: 30.5-45.0%

5 weeks-7 weeks: 26.8-37.5%

8 weeks-5 months: 28.6-37.2%

6 months-23 months: 30.8-37.8%

24 months-35 months: 31.0-37.7%

3-7 years: 34-42%

8-11 years: 35-43%

12-15 years: 38-47%

16-17 years: 40-50%

Adults: 38.3-48.6%

 

Females:

0-14 days: 39.6-57.2%

15 days-4 weeks: 32.0-44.5%

5 weeks-7 weeks: 27.7-35.1%

8 weeks-5 months: 29.5-37.1%

6 months-23 months: 30.9-37.9%

24 months-35 months: 31.2-37.8%

3-7 years: 34-42%

8-17 years: 35-43%

Adults: 35.5-44.9%

 

MEAN CORPUSCULAR VOLUME (MCV)

Males:

0-14 days: 91.3-103.1 fL

15 days-4 weeks: 89.4-99.7 fL

5 weeks-7 weeks: 84.3-94.2 fL

8 weeks-5 months: 74.1-87.5 fL

6 months-23 months: 69.5-81.7 fL

24 months-35 months: 71.3-84.0 fL

3-5 years: 77.2-89.5 fL

6-11 years: 77.8-91.1 fL

12-14 years: 79.9-93.0 fL

15-17 years: 82.5-98.0 fL

Adults: 78.2-97.9 fL

 

Females:

0-14 days: 92.7-106.4 fL

15 days-4 weeks: 90.1-103.0 fL

5 weeks-7 weeks: 83.4-96.4 fL

8 weeks-5 months: 74.8-88.3 fL

6 months-23 months: 71.3-82.6 fL

24 months-35 months: 72.3-85.0 fL

3-5 years: 77.2-89.5 fL

6-11 years: 77.8-91.1 fL

12-14 years: 79.9-93.0 fL

15-17 years: 82.5-98.0 fL

Adults: 78.2-97.93 fL

 

RED CELL DISTRIBUTION WIDTH (RDW)

Males:

0-14 days: 14.8-17.0%

15 days-4 weeks: 14.3-16.8%

5 weeks-7 weeks: 13.8-16.1%

8 weeks-5 months: 12.4-15.3%

6 months-23 months: 12.9-15.6%

24 months-35 months: 12.5-14.9%

3-5 years: 11.3-13.4%

6-17 years: 11.4-13.5%

Adults: 11.8-14.5%

 

Females:

0-14 days: 14.6-17.3%

15 days-4 weeks: 14.4-16.2%

5 weeks-7 weeks: 13.6-15.8%

8 weeks-5 months: 12.2-14.3%

6 months-23 months: 12.7-15.1%

24 months-35 months: 12.4-14.9%

3-5 years: 11.3-13.4%

6-17 years: 11.4-13.5%

Adults: 12.2-16.1%

 

WHITE BLOOD CELL COUNT (WBC)

Males:

0-14 days: 8.0-15.4 x 10(9)/L

15 days-4 weeks: 7.8-15.9 x 10(9)/L

5 weeks-7 weeks: 8.1-15.0 x 10(9)/L

8 weeks-5 months: 6.5-13.3 x 10(9)/L

6 months-23 months: 6.0-13.5 x 10(9)/L

24 months-35 months: 5.1-13.4 x 10(9)/L

3-5 years: 4.4-12.9 x 10(9)/L

6-17 years: 3.8-10.4 x 10(9)/L

Adults: 3.4-9.6 x 10(9)/L

 

Females:

0-14 days: 8.2-14.6 x 10(9)/L

15 days-4 weeks: 8.4-14.4 x 10(9)/L

5 weeks-7 weeks: 7.1-14.7 x 10(9)/L

8 weeks-5 months: 6.0-13.3 x 10(9)/L

6 months-23 months: 6.5-13.0 x 10(9)/L

24 months-35 months: 4.9-13.2 x 10(9)/L

3-5 years: 4.4-12.9 x 10(9)/L

6-17 years: 3.8-10.4 x 10(9)/L

Adults: 3.4-9.6 x 10(9)/L

 

PLATELETS

Males:

0-14 days: 218-419 x 10(9)/L

15 days-4 weeks: 248-586 x 10(9)/L

5 weeks-7 weeks: 229-562 x 10(9)/L

8 weeks-5 months: 244-529 x 10(9)/L

6 months-23 months: 206-445 x 10(9)/L

24 months-35 months: 202-403 x 10(9)/L

3-5 years: 187-445 x 10(9)/L

6-9 years: 187-400 x 10(9)/L

10-13 years: 177-381 x 10(9)/L

14-17 years: 139-320 x 10(9)/L

Adults: 135-317 x 10(9)/L

 

Females:

0-14 days: 144-449 x 10(9)/L

15 days-4 weeks: 279-571 x 10(9)/L

5 weeks-7 weeks: 331-597 x 10(9)/L

8 weeks-5 months: 247-580 x 10(9)/L

6 months-23 months: 214-459 x 10(9)/L

24 months-35 months: 189-394 x 10(9)/L

3-5 years: 187-445 x 10(9)/L

6-9 years: 187-400 x 10(9)/L

10-13 years: 177-381 x 10(9)/L

14-17 years: 158-362 x 10(9)/L

Adults: 157-371 x 10(9)/L

 

NEUTROPHILS

Males:

0-14 days: 1.60-6.06 x 10(9)/L

15 days-4 weeks: 1.18-5.45 x 10(9)/L

5 weeks-7 weeks: 0.83-4.23 x 10(9)/L

8 weeks-5 months: 0.97-5.45 x 10(9)/L

6 months-23 months: 1.19-7.21 x 10(9)/L

24 months-35 months: 1.54-7.92 x 10(9)/L

3-5 years: 1.60-7.80 x 10(9)/L

6-16 years: 1.40-6.10 x 10(9)/L

17 years: 1.80-7.20 x 10(9)/L

Adults: 1.56-6.45 x 10(9)/L

 

Females:

0-14 days: 1.73-6.75 x 10(9)/L

15 days-4 weeks: 1.23-4.80 x 10(9)/L

5 weeks-7 weeks: 1.00-4.68 x 10(9)/L

8 weeks-5 months: 1.04-7.20 x 10(9)/L

6 months-23 months: 1.27-7.18 x 10(9)/L

24 months-35 months: 1.60-8.29 x 10(9)/L

3-5 years: 1.60-7.80 x 10(9)/L

6-14 years: 1.50-6.50 x 10(9)/L

15-17 years: 2.00-7.40 x 10(9)/L

Adults: 1.56-6.45 x 10(9)/L

 

LYMPHOCYTES

Males:

0-14 days: 2.07-7.53 x 10(9)/L

15 days-4 weeks: 2.11-8.38 x 10(9)/L

5 weeks-7 weeks: 2.47-7.95 x 10(9)/L

8 weeks-5 months: 2.45-8.89 x 10(9)/L

6 months-23 months: 1.56-7.83 x 10(9)/L

24 months-35 months: 1.13-5.52 x 10(9)/L

3-5 years: 1.60-5.30 x 10(9)/L

6-11 years: 1.40-3.90 x 10(9)/L

12-17 years: 1.00-3.20 x 10(9)/L

Adults: 0.95-3.07 x 10(9)/L

 

Females:

0-14 days: 1.75-8.00 x 10(9)/L

15 days-4 weeks: 2.42-8.20 x 10(9)/L

5 weeks-7 weeks: 2.29-9.14 x 10(9)/L

8 weeks-5 months: 2.14-8.99 x 10(9)/L

6 months-23 months: 1.52-8.09 x 10(9)/L

24 months-35 months: 1.25-5.77 x 10(9)/L

3-5 years: 1.60-5.30 x 10(9)/L

6-11 years: 1.40-3.90 x 10(9)/L

12-17 years: 1.00-3.20 x 10(9)/L

Adults: 0.95-3.07 x 10(9)/L

 

MONOCYTES

Males:

0-14 days: 0.52-1.77 x 10(9)/L

15 days-4 weeks: 0.28-1.38 x 10(9)/L

5 weeks-7 weeks: 0.28-1.05 x 10(9)/L

8 weeks-5 months: 0.28-1.07 x 10(9)/L

6 months-23 months: 0.25-1.15 x 10(9)/L

24 months-35 months: 0.19-0.94 x 10(9)/L

3-5 years: 0.30-0.90 x 10(9)/L

6-17 years: 0.20-0.80 x 10(9)/L

Adults: 0.26-0.81 x 10(9)/L

 

Females:

0-14 days: 0.57-1.72 x 10(9)/L

15 days-4 weeks: 0.42-1.21 x 10(9)/L

5 weeks-7 weeks: 0.28-1.21 x 10(9)/L

8 weeks-5 months: 0.24-1.17 x 10(9)/L

6 months-23 months: 0.26-1.08 x 10(9)/L

24 months-35 months: 0.24-0.92 x 10(9)/L

3-5 years: 0.30-0.90 x 10(9)/L

6-17 years: 0.20-0.80 x 10(9)/L

Adults: 0.26-0.81 x 10(9)/L

 

EOSINOPHILS

Males:

0-14 days: 0.12-0.66 x 10(9)/L

15 days-4 weeks: 0.08-0.80 x 10(9)/L

5 weeks-7 weeks: 0.05-0.57 x 10(9)/L

8 weeks-5 months: 0.03-0.61 x 10(9)/L

6 months-23 months: 0.02-0.82 x 10(9)/L

24 months-35 months: 0.03-0.53 x 10(9)/L

3-11 years: 0.00-0.50 x 10(9)/L

12-17 years: 0.10-0.20 x 10(9)/L

Adults: 0.03-0.48 x 10(9)/L

 

Females:

0-14 days: 0.09-0.64 x 10(9)/L

15 days-4 weeks: 0.06-0.75 x 10(9)/L

5 weeks-7 weeks: 0.04-0.63 x 10(9)/L

8 weeks-5 months: 0.02-0.74 x 10(9)/L

6 months-23 months: 0.02-0.58 x 10(9)/L

24 months-35 months: 0.03-0.46 x 10(9)/L

3-11 years: 0.00-0.50 x 10(9)/L

12-17 years: 0.10-0.20 x 10(9)/L

Adults: 0.03-0.48 x 10(9)/L

 

BASOPHILS

Males:

0-14 days: 0.02-0.11 x 10(9)/L

15 days-7 weeks: 0.01-0.07 x 10(9)/L

8 weeks-35 months: 0.01-0.06 x 10(9)/L

3-17 years: 0.00-0.10 x 10(9)/L

Adults: 0.01-0.08 x 10(9)/L

 

Females:

0-14 days: 0.02-0.07 x 10(9)/L

15 days-4 weeks: 0.01-0.06 x 10(9)/L

5 weeks-7 weeks: 0.01-0.05 x 10(9)/L

8 weeks-5 months: 0.01-0.07 x 10(9)/L

6 months-35 months: 0.01-0.06 x 10(9)/L

3-17 years: 0.00-0.10 x 10(9)/L

Adults: 0.01-0.08 x 10(9)/L

Interpretation
Provides information to assist in interpretation of the test results

Results outside of normal value ranges may reflect a primary disorder of the cell-producing organs or an underlying disease. Results should be interpreted in conjunction with the patient's clinical picture and appropriate additional testing performed.

Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Questionable results are detected by in-house checking criteria based on quantitative and qualitative parameters.

 

Defined laboratory instrument or patient flagging criteria may trigger peripheral blood smear review resulting in consultant readout of hematologic abnormalities.

Clinical Reference
Recommendations for in-depth reading of a clinical nature

1. Adel K, Raizman J, Chen Y, et al: Complex biological profile of hematologic markers across pediatric, adult, and geriatric ages: establishment of robust pediatric and adult reference intervals on the basis of the Canadian Health Measures Survey. Clin Chem 2015;61:8

2. CLSI. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Guideline, Third Edition. CLSI document EP28-A3c. Wayne, PA, Clinical and Laboratory Standards Institute, 2008

3. Soldin J, Brugnara C, Wong EC: Pediatric Reference Intervals. Fifth Edition. AACC Press. Washington, DC, 2005. ISBN 1-594250-32-4

Method Description
Describes how the test is performed and provides a method-specific reference

The Sysmex XN 9000 performs hematology analysis according to the hydrodynamic focusing (DC detection), flow cytometry method (semiconductor laser), and sodium lauryl sulfate (SLS)-hemoglobin method.(Instruction manual: Automated Hematology Analyzer XN series [XN-9000], Code No. CJ410539. North American Edition. November 2015)

PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information

No

Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Monday through Sunday

Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

Same day/1 day

Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

1 day

Performing Laboratory Location
Indicates the location of the laboratory that performs the test

Rochester

Fees
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

  • Authorized users can sign in to Test Prices for detailed fee information.
  • Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
  • Prospective clients should contact their account representative. For assistance, contact Customer Service.

Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

CPT codes are provided by the performing laboratory.

85025

85007 (if appropriate)

85060 (if appropriate)

LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.

Test Id Test Order Name Order LOINC Value
CBC CBC with Differential, B 57021-8
Result Id Test Result Name Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
HGB Hemoglobin 718-7
HCT Hematocrit 4544-3
RBC Erythrocytes 789-8
MCV MCV 787-2
RDW RDW 788-0
WBC Leukocytes 6690-2
NEUAA Neutrophils, Abs 751-8
LYMAA Lymphocytes, Abs 731-0
MONAA Monocytes, Abs 742-7
EOSAA Eosinophils, Abs 711-2
BASAA Basophils, Abs 704-7
PLTC Platelet Count 777-3

Test Setup Resources

Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Excel | Pdf

Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.

Normal Reports | Abnormal Reports

SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.

SI Normal Reports | SI Abnormal Reports