Test Catalog

Test Id : FFTAC

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Thrombin-Antithrombin Complex

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Overview

Test Catalog

Method Name
A short description of the method used to perform the test

Enzyme Immunoassay

NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test

Thrombin Antithrombin Complex

Aliases
Lists additional common names for a test, as an aid in searching

FFTAC

TAT

Specimen Type
Describes the specimen type validated for testing

Plasma Na Cit

Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Specimen Type: Citrated plasma

Collection Container/Tube: Light-blue top (citrate)

Specimen Volume: 2 mL

Collection Instructions: Draw blood in a light blue-top (Sodium citrate) tube(s). Spin down and send 2 mL citrated plasma frozen in a plastic vial.

 

Note: Separate specimens must be submitted when multiple tests are ordered.

Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.

1 mL

Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected

Thawing** Cold reject; Warm reject
Other/Tissue/Swab Specimens other than Plasma; Anticoagulants other than Sodium citrate

Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 180 days

Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Thrombin-antithrombin complexes (TAT) form covalently following thrombin generation and have a plasma half-life of 10 to 15 minutes. The presence of TAT indicates ongoing thrombin formation and the consumption of antithrombin. Upon activation of coagulation, antithrombin complexes with thrombin as well as other serine proteases. Complex formation is greatly enhanced by the presence of heparin or other glycosaminoglycans. The reaction initially is reversible, but becomes irreversible following the formation of a covalent bond between antithrombin and thrombin. This binding results in complete inhibition of thrombin's activity. Elevated levels of TAT may be associated with advancing age, pregnancy, septicemia, disseminated intravascular coagulation, multiple traumas, acute pancreatitis, acute and chronic leukemia, preëclampsia, acute and chronic liver disease, and other predisposing causes of thrombosis. Increased levels are also reported during heparin and fibrinolytic therapy. TAT levels are markedly reduced in the first 24 hours after receiving oral anticoagulants. The TAT assay can detect the intravascular generation of thrombin and provides valuable information in the diagnosis of thrombotic events. Decreasing TAT levels can also indicate the resolution of a thrombotic event. A normal TAT level in the presence of an elevated D-dimer may indicate an old thrombus. Elevated TAT measurements may be accompanied by increased levels of prothrombin fragment 1+2, fibrinpeptide A, fibrin(ogen)degradation products, and D-dimer. D-dimer has greater sensitivity for detection of deep venous thrombosis.

Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

<4.3 ng/mL

Pre-analytical conditions such as a difficult draw may spuriously increase test results.

Method Description
Describes how the test is performed and provides a method-specific reference

TAT is measured by enzyme immunoassay using a sandwich technique. The patient sample containing TAT is incubated with antibodies against thrombin, and the unbound constituents are removed by washing. Enzyme conjugated antibodies to antithrombin are then added to the reaction, and the excess antibodies are removed by washing. The remaining (bound) enzymatic activity acts upon a chromophore and color development is proportional to the TAT in the sample.

PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information

No

Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Monday, Thursday

Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

4 to 13 days

Performing Laboratory Location
Indicates the location of the laboratory that performs the test

Esoterix Coagulation

Fees
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

  • Authorized users can sign in to Test Prices for detailed fee information.
  • Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
  • Prospective clients should contact their account representative. For assistance, contact Customer Service.

CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

CPT codes are provided by the performing laboratory.

83520

LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.

Test Id Test Order Name Order LOINC Value
FFTAC Thrombin Antithrombin Complex 14182-0
Result Id Test Result Name Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
FFTAC Thrombin Antithrombin Complex 14182-0

Test Setup Resources

Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Excel | Pdf

Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.

Normal Reports | Abnormal Reports

SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.

SI Normal Reports | SI Abnormal Reports