Test Catalog

Test Id : IL1B

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Interleukin-1 Beta, Plasma

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Overview

Test Catalog

Useful For
Suggests clinical disorders or settings where the test may be helpful

Measuring the concentration of interleukin-1 beta in plasma

 

Evaluating patients experiencing inflammatory conditions, autoinflammatory disorders, and infection

Highlights

This test may aid the evaluation and monitoring of patients experiencing inflammatory conditions, autoinflammatory disorders, and infection.

Method Name
A short description of the method used to perform the test

Bead-Based Multiplex Immunoassay

NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test

IL-1 Beta, P

Aliases
Lists additional common names for a test, as an aid in searching

Cytokine

Cytokines

IL-1 family cytokines

IL 1-Beta

IL-1

IL-1 Beta

IL1

IL1B

Interleukin 1-Beta

Interleukin 1b

Specimen Type
Describes the specimen type validated for testing

Plasma EDTA

Ordering Guidance

If this test is ordered with CYPAN / Cytokine Panel, Plasma, this test will be canceled as duplicate and CYPAN performed as ordered.

Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions:

1. Immediately after specimen collection, place tube on wet ice.

2. Centrifuge at 4 degrees C, 1500 x g for 10 minutes.

3. Aliquot plasma into plastic vial.

4. Freeze specimen within 2 hours of collection.

Additional Information:

1. Plasma for this test cannot be shared with other tests. Submit specimen for this test in its own vial.

2. This test cannot be added on to a previously collected specimen.

Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.

0.3 mL

Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject
Heat-treated specimen Reject

Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen Type Temperature Time Special Container
Plasma EDTA Frozen 21 days

Useful For
Suggests clinical disorders or settings where the test may be helpful

Measuring the concentration of interleukin-1 beta in plasma

 

Evaluating patients experiencing inflammatory conditions, autoinflammatory disorders, and infection

Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Interleukin-1 (IL-1) beta is a potent pro-inflammatory cytokine that is crucial for host-defence responses to infection and injury. IL-1 beta binds to IL-1 receptor 1 (IL-1R1) and initiates inflammatory responses in T-lymphocytes, epithelial cells and endothelial cells.(1,2) Excess IL-1 beta signaling have been associated with acute inflammation and chronic autoinflammatory diseases.(3) Plasma IL-1 beta concentrations are elevated in some rheumatoid arthritis patients compared to healthy volunteers. There are increased concentrations of IL-1 beta and tumor necrosis factor-alpha in synovial fluid of rheumatoid arthritis patients.

 

Several biologics, such as anakinra and canakinumab, have been developed to inhibit the IL-1 signaling pathway by blocking IL-1 beta binding to IL-1 receptors in rheumatoid arthritis, familial Mediterranean fever, cryopyrin-associated periodic syndromes, etc.(2,4)

Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

<18 years: Not established

> or =18 years: <20.0 pg/mL

Interpretation
Provides information to assist in interpretation of the test results

Elevated interleukin-1 beta concentrations could indicate the presence of inflammatory or infectious condition.

Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Results from interleukin-1 (IL-1) beta testing should not be used to establish or exclude a specific diagnosis.

 

Testing for IL-1 beta should only be used in conjunction with clinical information and other laboratory testing as part of a patient's overall assessment.

 

Normal concentration of IL-1 beta does not exclude the possibility of infection or inflammatory disorders.

 

Concentrations of IL-1B could be affected by immunomodulatory agents.

Clinical Reference
Recommendations for in-depth reading of a clinical nature

1. Pretre V, Papadopoulos D, Regard J, Pelletier M, Woo J. Interleukin-1 (IL-1) and the inflammasome in cancer. Cytokine. 2022;153:155850

2. Imazio M, Lazaros G, Gattorno M, et al. Anti-interleukin-1 agents for pericarditis: a primer for cardiologists. Eur Heart J. 2022;43(31):2946-2957

3. Carta S, Semino C, Sitia R, Rubartelli A. Dysregulated IL-1 beta Secretion in Autoinflammatory Diseases: A Matter of Stress?. Front Immunol. 2017;8:345

4. Kaneko N, Kurata M, Yamamoto T, Morikawa S, Masumoto J. The role of interleukin-1 in general pathology. Inflamm Regen. 2019;39:12

Method Description
Describes how the test is performed and provides a method-specific reference

Testing for interleukin-1 beta levels is performed using a laboratory-developed bead-based immunoassay.(Unpublished Mayo method)

PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information

No

Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Tuesday

Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

2 to 8 days

Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

14 days

Performing Laboratory Location
Indicates the location of the laboratory that performs the test

Rochester

Fees
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

  • Authorized users can sign in to Test Prices for detailed fee information.
  • Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
  • Prospective clients should contact their account representative. For assistance, contact Customer Service.

Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

CPT codes are provided by the performing laboratory.

83520

LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.

Test Id Test Order Name Order LOINC Value
IL1B IL-1 Beta, P 13629-1
Result Id Test Result Name Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
622327 IL-1 beta 13629-1

Test Setup Resources

Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Excel | Pdf

Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.

Normal Reports | Abnormal Reports

SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.

SI Normal Reports | SI Abnormal Reports

Test Update Resources

Change Type Effective Date
New Test 2025-02-13