Limited use in screening of patients for liver disease
Colorimetric
Urine
Ship specimen in amber vial to protect from light.
Supplies: Sarstedt 5 mL Aliquot Tube (Amber) (T915)
Container/Tube: Amber vial
Specimen Volume: 5 mL
Collection Instructions: Collect a random urine specimen.
1 mL
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Urine | Refrigerated (preferred) | 7 days | LIGHT PROTECTED |
Frozen | 90 days | LIGHT PROTECTED |
Limited use in screening of patients for liver disease
Bilirubin is primarily derived from metabolism of hemoglobin. Only conjugated bilirubin is excreted into the urine and normally only trace amounts can be detected in urine. Elevated urinary bilirubin occurs in patients with obstructive jaundice or jaundice due to hepatocellular disease or injury. However, urine bilirubin is relatively insensitive for detection of liver disease. Hyperbilirubinemia due to hemolysis is principally due to unconjugated bilirubin, and therefore does not result in increased urinary bilirubin.
Negative
Elevated urinary bilirubin is suggestive of hepatocellular disease or post-hepatic biliary obstruction.
False positive tests may occur if urine is contaminated with stool, or if the patient is taking drugs which cause red coloration of urine. False negative tests may occur after prolonged storage, exposure to light, or if patient has taken large amounts of ascorbic acid.
1. Brunzel NA: Fundamentals of Urine and Body Fluid Analysis. 4th ed. Saunders; 2017
2. Hoilat GJ, John S: Bilirubinuria. In: StatPearls [Internet]. StatPearls Publishing; 2020. Accessed February 12, 2021. Available at www.ncbi.nlm.nih.gov/books/NBK557439/
The test is based on the diazotiation reaction coupling of a solid diazonium salt (2,4-dichlorobenzenediazonium tetrachlorozincate) with bilirubin in an acid medium (sulfosalicylic acid) to give the desired reaction.(Package insert: Siemens Ictotest kit, Siemens Healthcare Diagnostics; 10491623 Rev. 09/2017)
Monday through Sunday
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.
81002
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
BILUR | Bilirubin, Random, U | 5770-3 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
BILUR | Bilirubin, Random, U | 5770-3 |