Aiding in the diagnosis of chyluria (galacturia)
Enzymatic Colorimetric/Electrophoresis/Spectrophotometry (SP)
Chyluria Screen, Urine
Fat Embolism Syndrome
Fat, Total
Gross Fat Droplets
Lipid Analysis, Urine
Lipid Survey, Urine
Urine Fluid
Chylomicrons
Galacturia
Triglycerides, Urine
Urine
Patient Preparation: Before specimen collection, the patient should not ingest foods or beverages rich in vitamin C or take vitamin C supplements.
Supplies: Urine Container, 60 mL (T313)
Container/Tube: Plastic, 60-mL urine bottle
Specimen Volume: 15 mL
Collection Instructions: Collect a first-morning, random urine collection.
15 mL
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Urine | Frozen (preferred) | 10 days | |
Refrigerated | 10 days | ||
Ambient | 4 hours |
Aiding in the diagnosis of chyluria (galacturia)
Chyluria is a medical condition in which chyle is present in the urine. Chyle is a milky substance composed of lymphatic fluid and chylomicrons formed in the small intestine during the digestion of fatty foods. Chyluria is most prevalent in tropical areas where it is caused by parasitic (Wuchereria bancrofti) infections spread by mosquitoes. Parasitic chyluria is so rare as to be nonexistent in the continental United States. Nonparasitic chyluria causes include traumatic lesions, tumors, lymphangioma, pregnancy, and granulomatous infections.
No lipoproteins present
This assay provides information regarding the fat content in urine fluid. Urinary cholesterol and triglyceride values are normally less than 10 mg/dL. High triglyceride levels in urine may indicate chyluria.
Ascorbic acid (vitamin C) interferes with the cholesterol determination and, to a lesser degree, the triglyceride concentration. Ascorbic acid falsely decreases the cholesterol and triglyceride results.
Result can be falsely decreased in patients with elevated levels of N-acetyl-p-benzoquinone imine (NAPQI)-a metabolite of acetaminophen, N-acetylcysteine, and metamizole.
1. Diamond E, Schapira HE. Chyluria-a review of the literature. Urology. 1985;26(5):427-431
2. Mendu DR, Sternlicht H, Ramanathan LV, et al. Two cases of spontaneous remission of non-parasitic chyluria. Clin Biochem. 2017;50(15):886-888. doi:10.1016/j.clinbiochem.2017.05.002
This test involves 2 steps, centrifugation and lipoprotein electrophoresis, to detect the visual presence of chylomicrons. The specimen also is analyzed for cholesterol and triglycerides using an enzymatic colorimetric method. The results of the cholesterol, triglycerides, and lipoprotein electrophoresis are used together to determine whether the sample is chyluria.(Unpublished Mayo information)
Monday through Friday
This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.
82664-Electrophoretic technique, not elsewhere specified (Chylomicrons and lipoproteins)
84311-Spectrophotometry, analyte not specified (Cholesterol)
84478-Triglycerides
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
CSU | Chyluria Screen, Random, U | 95808-2 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
CHOLU | Cholesterol, Random, U | 14444-4 |
TRIGU | Triglycerides, Random, U | 14450-1 |
CMTCS | Interpretive Comment | 95807-4 |