Test Catalog

Test Id : HOLDF

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Hematologic Disorders, Fluorescence In Situ Hybridization (FISH) Hold, Varies

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Overview

Test Catalog

Useful For
Suggests clinical disorders or settings where the test may be helpful

Processing the bone marrow or peripheral blood specimen but delaying fluorescence in situ hybridization analysis while preliminary morphologic assessment is in process

Reflex Tests
Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test Id Reporting Name Available Separately Always Performed
PHLDB Probe, Each Additional (PHLDF) No, (Bill Only) No
BALPB Probe, Each Additional (BALPF) No, (Bill Only) No
EOSMB Probe, Each Additional (EOSMF) No, (Bill Only) No
EOS3B Probe, Tri-color (EOSMF) No, (Bill Only) No
BALMB Probe, Each Additional (BALMF) No, (Bill Only) No
BAL3B Probe, Tri-color (BAL) No, (Bill Only) No
BLPMB Probe, Each Additional (BLPMF) No, (Bill Only) No
BALAB Probe, Each Additional (BALAF) No, (Bill Only) No
MFCDB Probe, Each Additional (MFCDF) No, (Bill Only) No
EOSDB Probe, Each Additional (EOSDF) No, (Bill Only) No
TLPDB Probe, Each Additional (TLPDF) No, (Bill Only) No
COGBB Probe, Each Additional (COGBF) No, (Bill Only) No
COGTB Probe, Each Additional (COGTF) No, (Bill Only) No
COGMB Probe, Each Additional (COGMF) No, (Bill Only) No
HEMMB Probe, Each Additional (HEMMF) No, (Bill Only) No
MDSDB Probe, Each Additional (MDSDF) No, (Bill Only) No
MDSMB Probe, Each Additional (MDSMF) No, (Bill Only) No
AMLAF Adult AML, FISH Yes No
AMLMF AML, Specified FISH Yes No
AMLPF Pediatric AML, FISH Yes No
BALAF Adult ALL (B-cell), FISH Yes No
BALMF ALL (B-cell), Specified FISH Yes No
BALPF Pediatric ALL (B-cell), FISH Yes No
BLPMF B-cell Lymphoma, Specified FISH Yes No
CILDF Cong Infantile Leukemia, Diag FISH Yes No
CILMF Cong Infantile Leukemia, Spec FISH Yes No
CLLDF CLL, Diagnostic FISH Yes No
CLLMF CLL, Specified FISH Yes No
COGBF COG, ALL (B-cell), FISH Yes No
COGMF COG, AML, FISH Yes No
COGTF COG, ALL (T-cell), FISH Yes No
EOSDF Chronic Eosinophilia, Diag FISH Yes No
EOSMF Chronic Eosinophilia, Spec FISH Yes No
HEMMF Hematologic Specified FISH Yes No
MDSDF MDS, Diagnostic FISH Yes No
MDSMF MDS, Specified FISH Yes No
MFCDF Myeloma Fixed Cell, High Risk, FISH Yes No
PHLDF Ph-like ALL(B-cell), Diag FISH Yes No
TALAF Adult ALL (T-cell), FISH Yes No
TALMF ALL (T-cell), Specified FISH Yes No
TALPF Pediatric ALL (T-cell), FISH Yes No
TLPDF T-cell Lymphoma B/BM, Diag FISH Yes No
TLPMF T-cell Lymphoma B/BM, Spec FISH Yes No
TALAB Probe, Each Additional (TALAF) No, (Bill Only) No
TALPB Probe, Each Additional (TALPF) No, (Bill Only) No
TLPMB Probe, Each Additional (TLPMF) No No
TALMB Probe, Each Additional (TALMF) No, (Bill Only) No
AMLAB Probe, Each Additional (AMLAF) No, (Bill Only) No
AMLMB Probe, Each Additional (AMLMF) No, (Bill Only) No
AMLPB Probe, Each Additional (AMLPF) No, (Bill Only) No
CLLDB Probe, Each Additional (CLLDF) No, (Bill Only) No
CLLMB Probe, Each Additional (CLLMF) No, (Bill Only) No

Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test is designed to hold the sample and delay fluorescence in situ hybridization (FISH) testing while preliminary morphologic assessment or flow cytometry testing is in process.

 

Hold policy: Upon sample receipt, the specimen will be held in the laboratory. FISH testing will not be performed unless the client contacts the laboratory and indicates that FISH testing is desired. The client must contact the Cytogenetics Laboratory at 800-533-1710 by 4 p.m. (Central time) no later than 4 business days (96 hours) after the specimen was collected. If no notification is received by this time, the order will be processed as "canceled." Weekend communication can be deferred until Monday.

Method Name
A short description of the method used to perform the test

Direct Preparation of Specimen

NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test

Heme FISH Hold, B/BM

Aliases
Lists additional common names for a test, as an aid in searching

FISH sample processing

Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test is designed to hold the sample and delay fluorescence in situ hybridization (FISH) testing while preliminary morphologic assessment or flow cytometry testing is in process.

 

Hold policy: Upon sample receipt, the specimen will be held in the laboratory. FISH testing will not be performed unless the client contacts the laboratory and indicates that FISH testing is desired. The client must contact the Cytogenetics Laboratory at 800-533-1710 by 4 p.m. (Central time) no later than 4 business days (96 hours) after the specimen was collected. If no notification is received by this time, the order will be processed as "canceled." Weekend communication can be deferred until Monday.

Specimen Type
Describes the specimen type validated for testing

Varies

Ordering Guidance

This test is designed to hold blood and bone marrow specimens only.

 

This test does not apply to chromosome analysis. If specimen is to be held for chromosome analysis, order HOLDC / Hematologic Disorders, Chromosome Hold, Varies.

 

Due to stability issues, test PCPDS / Plasma Cell Proliferative Disorder, High-Risk with Reflex Probes, Diagnostic FISH Evaluation, Bone Marrow cannot be added onto specimens held under this test.

Shipping Instructions

Advise Express Mail or equivalent if not on courier service.

Necessary Information

Provide a reason for testing with each specimen and bone marrow pathology report (if available). The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.

ORDER QUESTIONS AND ANSWERS

Question ID Description Answers
CG666 Reason for Referral
CG667 Specimen
CG791 Requested FISH Test

Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Submit only 1 of the following specimens:

 

Preferred:

Specimen Type: Bone marrow

Container/Tube:

Preferred: Yellow top (ACD)

Acceptable: Green top (sodium heparin), lavender top (EDTA)

Specimen Volume: 1 to 2 mL

Collection Instructions: Invert several times to mix bone marrow.

 

Acceptable:

Specimen Type: Blood

Container/Tube:

Preferred: Yellow top (ACD)

Acceptable: Green top (sodium heparin), lavender top (EDTA)

Specimen Volume: 6 mL

Collection Instructions: Invert several times to mix blood.

Forms

If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.

Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.

Blood: 2 mL

Bone marrow: 1 mL

Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected

No specimen should be rejected.

Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen Type Temperature Time Special Container
Varies Ambient (preferred)
Standard

Useful For
Suggests clinical disorders or settings where the test may be helpful

Processing the bone marrow or peripheral blood specimen but delaying fluorescence in situ hybridization analysis while preliminary morphologic assessment is in process

Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test is designed to hold the sample and delay fluorescence in situ hybridization (FISH) testing while preliminary morphologic assessment or flow cytometry testing is in process.

 

Hold policy: Upon sample receipt, the specimen will be held in the laboratory. FISH testing will not be performed unless the client contacts the laboratory and indicates that FISH testing is desired. The client must contact the Cytogenetics Laboratory at 800-533-1710 by 4 p.m. (Central time) no later than 4 business days (96 hours) after the specimen was collected. If no notification is received by this time, the order will be processed as "canceled." Weekend communication can be deferred until Monday.

Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Fluorescence in situ hybridization (FISH) analysis using gene-specific probes is a useful methodology to detect common, recurrent chromosome abnormalities for most hematologic malignancies. Based on morphologic review of the bone marrow or peripheral blood specimen by a hematopathologist, a determination of additional appropriate testing can be made. If the specimen does not show evidence of malignancy, FISH analysis may not be necessary. Depending on the diagnosis, conventional chromosome analysis may also be more informative.

Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Not applicable

Interpretation
Provides information to assist in interpretation of the test results

If notified by the client, this test may be canceled, and a processing fee will be assessed.

 

If no notification to proceed with testing is received, this test will be reported as "cancelled."

Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

No significant cautionary statements

Method Description
Describes how the test is performed and provides a method-specific reference

The specimen will be held in the laboratory while preliminary morphologic assessment is in process to determine if fluorescence in situ hybridization (FISH) testing is appropriate.

PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information

No

Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Monday through Sunday

Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

4 days

Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

4 weeks

Performing Laboratory Location
Indicates the location of the laboratory that performs the test

Rochester

Fees
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

  • Authorized users can sign in to Test Prices for detailed fee information.
  • Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
  • Prospective clients should contact their account representative. For assistance, contact Customer Service.

Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.

Not Applicable

CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

CPT codes are provided by the performing laboratory.

See individual reflex tests

LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.

Test Id Test Order Name Order LOINC Value
HOLDF Heme FISH Hold, B/BM No LOINC Needed
Result Id Test Result Name Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
51836 Result Summary 50397-9
51838 Interpretation 69965-2
CG666 Reason for Referral 42349-1
CG667 Specimen 31208-2
51839 Source 31208-2
CG791 Requested FISH Test 48767-8
51841 Method 85069-3
53433 Additional Information 48767-8
51842 Released by 18771-6

Test Setup Resources

Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Excel | Pdf

Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.

Normal Reports | Abnormal Reports

SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.

SI Normal Reports | SI Abnormal Reports