Test Catalog

Test Id : UIOD

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Iodine, 24 Hour, Urine

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Overview

Test Catalog

Useful For
Suggests clinical disorders or settings where the test may be helpful

Assessing iodine toxicity or recent exposure in a 24-hour urine collection

 

Monitoring iodine excretion rate as index of replacement therapy

Method Name
A short description of the method used to perform the test

Inductively Coupled Plasma Mass Spectrometry (ICP-MS)

NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test

Iodine, 24 Hr, U

Aliases
Lists additional common names for a test, as an aid in searching

Urinary Free Iodine

Urinary Iodine

Specimen Type
Describes the specimen type validated for testing

Urine

Necessary Information

24-Hour volume (in milliliters) is required.

ORDER QUESTIONS AND ANSWERS

Question ID Description Answers
TIME5 Collection Duration (h)
VL23 Volume (mL)

Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Patient Preparation:

1. High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

2. If this test is used in conjunction with the (131)I uptake test, then specimen collection should begin immediately after the dose of (131)I is given (ie, the patient should void and discard urine just prior to the (131)I dose, and all subsequent urine should be collected for the next 24 hours). The last void should be included in the collection.

Supplies: Urine Tubes, 10 mL (T068)

Collection Container/Tube: Clean, plastic aliquot container with no metal cap or glued insert

Submission Container/Tube: Plastic, 10-mL urine tube

Specimen Volume: 10 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. Refrigerate specimen within 4 hours of completion of 24-hour collection.

3. See Metals Analysis Specimen Collection and Transport for complete instructions.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.

Special Instructions
Library of PDFs including pertinent information and forms related to the test

Urine Preservative Collection Options

Note: The addition of preservative or application of temperature controls must occur within 4 hours of completion of the collection.

Ambient (no additive)

OK

Refrigerate (no additive)

Preferred

Frozen (no additive)

OK

50% Acetic Acid

OK

Boric Acid

No

Diazolidinyl Urea

No

6M Hydrochloric Acid

No

6M Nitric Acid

No

Sodium Carbonate

No

Thymol

No

Toluene

No

Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.

0.3 mL

Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen Type Temperature Time Special Container
Urine Ambient 146 days
Refrigerated (preferred) 146 days
Frozen 146 days

Useful For
Suggests clinical disorders or settings where the test may be helpful

Assessing iodine toxicity or recent exposure in a 24-hour urine collection

 

Monitoring iodine excretion rate as index of replacement therapy

Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Iodine is an essential element for thyroid hormone production. The measurement of urinary iodine is preferred for assessment of toxicity, recent exposure, and monitoring iodine excretion rate as an index of replacement therapy.

Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

0-17 years: Not established

> or =18 years: 75-851 mcg/24 hour

Interpretation
Provides information to assist in interpretation of the test results

Measurement of urinary iodine excretion provides the best index of dietary iodine intake and deficiency is generally indicated when the concentrations are below 100 mcg/L.

 

World Healthcare Organization (WHO) Criteria for Assessing Iodine Status

 

Children older than 6 years and adults(1)

Median urinary iodine (mcg/L)

Iodine intake

Iodine status

<20

Insufficient

Severe deficiency

20-49

Insufficient

Moderate deficiency

50-99

Insufficient

Mild deficiency

100-199

Adequate

Adequate nutrition

200-299

Above requirements

May pose a slight risk of more than adequate

>299

Excessive

Risk of adverse health consequences

 

Pregnant women(1)

Median urinary iodine (mcg/L)

Iodine intake

<150

Insufficient

150-249

Adequate

250-499

Above

requirements

>499

Excessive

 

Lactating women and children younger than 2 years(1)

Median urinary iodine (mcg/L)

Iodine intake

<100

Insufficient

>99

Adequate

Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Administration of iodine-based contrast media and drugs containing iodine, such as amiodarone, will yield elevated results.

Clinical Reference
Recommendations for in-depth reading of a clinical nature

1. Department of Nutrition for Health and Development (NHD); World Health Organization. Urinary iodine concentrations for determining iodine status in populations. World Health Organization; 2013. Accessed April 25, 2025. Available at www.who.int/publications/i/item/WHO-NMH-NHD-EPG-13.1

2. Rifai N, Chiu RWK, Young I, Burnham CAD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023

3. Knudsen N, Christiansen E, Brandt-Christensen M, et al. Age- and sex-adjusted iodine/creatinine ratio. A new standard in epidemiological surveys? Evaluation of three different estimates of iodine excretion based on casual urine samples and comparison to 24 h values. Eur J Clin Nutr. 2000;54(4):361-363

4. Liberman CS, Pino SC, Fang SL, et al. Circulating iodine concentrations during and after pregnancy. J Clin Endocrinol Metab. 1998;83(10):3545-3549

5. Pfeiffer CM, Sternberg MR, Schleicher RL, et al. CDC's Second National Report on Biochemical Indicators of Diet and Nutrition in the US Population is a valuable tool for researchers and policy makers. J Nutr. 2013;143(6):938S-947S

6. Leung AM, Braverman LE. Consequences of excess iodine. Nat Rev Endocrinol. 2014;10(3):136-142. doi:10.1038/nrendo.2013.251

7. U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry: Toxicological Profile for Iodine. HHS, 2004. Accessed April 25, 2025. Available at www.atsdr.cdc.gov/ToxProfiles/tp158.pdf

Method Description
Describes how the test is performed and provides a method-specific reference

The metal of interest is analyzed by inductively coupled plasma mass spectrometry.(Unpublished Mayo method)

PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information

No

Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Tuesday, Friday

Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

1 to 5 days

Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

14 days

Performing Laboratory Location
Indicates the location of the laboratory that performs the test

Rochester

Fees :
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

  • Authorized users can sign in to Test Prices for detailed fee information.
  • Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
  • Prospective clients should contact their account representative. For assistance, contact Customer Service.

Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

CPT codes are provided by the performing laboratory.

83789

LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.

Test Id Test Order Name Order LOINC Value
UIOD Iodine, 24 Hr, U 2492-7
Result Id Test Result Name Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
9549 Iodine, 24 Hr, U 2492-7
TIME5 Collection Duration (h) 13362-9
VL23 Volume (mL) 3167-4
614369 Iodine Concentration 26842-5
614423 Iodine Concentration Interpretation 77202-0

Test Setup Resources

Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Excel | Pdf

Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.

Normal Reports | Abnormal Reports

SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.

SI Normal Reports | SI Abnormal Reports

Test Update Resources

Change Type Effective Date
File Definition - Result ID 2025-04-22