Detection of drug abuse involving phencyclidine (street names: angel dust, hog, or angel hair)
Gas Chromatography Mass Spectrometry (GC-MS) Confirmation with Quantitation
Angel Dust (Phencyclidine)
PCP (Phencyclidine)
Rocket Fuel (Phencyclidine)
Super Weed
TCP (Phencyclidine)
Killer Weed (Phencyclidine)
Urine
1. For situations where chain of custody is required, a Chain of Custody Kit (T282) is available. For chain-of-custody testing, order PCPX / Phencyclidine Confirmation, Chain of Custody, Random, Urine
2. If urine creatinine is required or adulteration of the sample is suspected, order ADULT / Adulterants Survey, Random, Urine.
3. Additional drug panels and specific requests are available. Call 800-533-1710 or 507-266-5700.
Supplies: Urine Tubes, 10 mL (T068)
Container Tube: Plastic, 10 mL urine tube
Specimen Volume: 10 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative.
Additional Information:
1. No specimen substitutions.
2. STAT requests are not accepted for this test.
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.
1.2 mL
Gross hemolysis | OK |
Gross icterus | OK |
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Urine | Refrigerated (preferred) | 14 days | |
Frozen | 14 days | ||
Ambient | 72 hours |
Detection of drug abuse involving phencyclidine (street names: angel dust, hog, or angel hair)
Phencyclidine (PCP) is a drug of abuse. This compound affects diverse neural pathways and interacts with cholinergic, adrenergic, gamma-aminobutyric acid (GABA)-secreting, serotoninergic, opiate neuronal receptors, and gamma receptors. It has analgesic, anesthetic, and stimulatory effects, yielding bizarre behavior, ranging from depression through catatonia, euphoria, violent rage, and hallucinations. Most fatalities result from its hypertensive effect.
Diagnosis of PCP usage depends on drug screening. PCP is excreted in the urine.
Negative
Cutoff concentrations
Phencyclidine by GC-MS: <10 ng/mL
The presence of phencyclidine (PCP) in urine is a strong indicator that the patient has used PCP.
Urine phencyclidine (PCP) may be undetectable at alkaline pH. Urine pH must, therefore, always be recorded.
1. Schuster DI, Arnold FJ, Murphy RB. Purification, pharmacological characterization and photoaffinity labeling of sigma receptors from rat and bovine brain. Brain Res. 1995;670(1):14-28
2. Bayorh MA, Zokowska-Grojec A, Palkovits M, Kopin IJ. Effect of phencyclidine (PCP) on blood pressure and catecholamine levels in discrete brain nuclei. Brain Res. 1984;321(2):315-318
3. Baselt RC. Disposition of Toxic Drugs and Chemicals in Man. 11th edition. Biomedical Publications; 2017
The specimen is analyzed by gas chromatography mass spectrometry.(Unpublished Mayo method)
Monday, Wednesday
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.
83992
G0480 (if appropriate)
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
PCPU | Phencyclidine Confirmation, U | 16254-5 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
6673 | Phencyclidine-by GC/MS | 16254-5 |
21192 | Phencyclidine Interpretation | 69050-3 |
21193 | Chain of Custody | 77202-0 |