Test Catalog

Test Id : FIERA

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IgE Receptor Antibody

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Overview

Test Catalog

Useful For
Suggests clinical disorders or settings where the test may be helpful

The test detects functional autoantibodies to the Fc-epsilon receptor (high affinity IgE receptor) or to IgE and is useful in the evaluation of chronic urticaria.

Method Name
A short description of the method used to perform the test

Flow Cytometry

NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test

IgE Receptor Antibody

Aliases
Lists additional common names for a test, as an aid in searching

Basophil Degranulation assay (Anti-IgE Receptor Ab)

basophil degranulation

bhr

cd203a

cd203c

CD203c (Anti-IgE Receptor Ab)

Chronic Urticaria (Anti-IgE Receptor Ab)

CU (Anti-IgE Receptor Ab)

FC Epsilon (Anti-IgE Receptor Ab)

Hives (Anti-IgE Receptor Ab)

IGERAB

IFERAB (Anti-IgE Receptor Ab)

Urticaria (Anti-IgE Receptor Ab)

Specimen Type
Describes the specimen type validated for testing

Serum

Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Container/Tube:

Preferred: Red top tube

Acceptable: Serum gel tube

Specimen Volume: 1.0 mL

Collection Instructions: Draw blood in a plain, red-top tube(s) or serum gel tube(s). Separate serum from cells immediately by centrifugation and aliquot in a polypropylene or similar plastic tube. Send 1 mL of serum frozen in plastic vial.

Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.

0.5 mL

Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected

Hemolysis Mild OK; Gross reject
Lipemia NA
Icterus NA
Other NA

Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen Type Temperature Time Special Container
Serum Frozen (preferred) 365 days
Refrigerated 7 days
Ambient 48 hours

Useful For
Suggests clinical disorders or settings where the test may be helpful

The test detects functional autoantibodies to the Fc-epsilon receptor (high affinity IgE receptor) or to IgE and is useful in the evaluation of chronic urticaria.

Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

0-12

Interpretation
Provides information to assist in interpretation of the test results

Chronic autoimmune urticaria (CIU) may be associated with autoantibodies to the high affinity IgE receptor (Fc-epsilon R1) or to IgE. In the presence of the autoantibodies, cross-linking of the Fc-epsilon-R1 receptor occurs, leading to basophil activation. The laboratory tests for the activation of donor basophils by CIU serum by analyzing the expression of the basophil specific ectoenzyme, CD203c. CD203c is upregulated on the surface of basophils following activation. A positive result is indicative of the presence of autoantibodies associated with CUI, but may also be due to other basophil-activating serum factors. Results must be correlated with clinical findings. The reference range was developed by the National Jewish Health Advanced Diagnostic Laboratories by analyzing 80 healthy control serum samples.

Clinical Reference
Recommendations for in-depth reading of a clinical nature

Chronic urticaria sera increase basophil CD203c expression. Yasnowsky KM1, Drekin SC, Efaw B, Shoen D, Vedanthan PL, Alam R, Harbek RJ, J Allergy Clin Immunol 2006 Jun; 117(6): 1430-4.

PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information

No

Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Monday, Thursday

Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

11 to 14 days

Performing Laboratory Location
Indicates the location of the laboratory that performs the test

National Jewish Health

Fees :
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

  • Authorized users can sign in to Test Prices for detailed fee information.
  • Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
  • Prospective clients should contact their account representative. For assistance, contact Customer Service.

Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.

This test uses a kit/reagent designated by the manufacturer as "for research use, not for clinical use" as well as one or more reagents classified as an analyte specific reagent (ASR). The performance characteristics of this test have been validated by Advanced Diagnostic Laboratories at National Jewish Health. It has not been cleared or approved by the US Food and Drug Administration. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high complexity clinical laboratory testing.

CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

CPT codes are provided by the performing laboratory.

88184

88185 x 2

LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.

Test Id Test Order Name Order LOINC Value
FIERA IgE Receptor Antibody Not Provided
Result Id Test Result Name Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
Z5810 CD203c (Percent of Basophils) Not Provided
Z5811 Interpretation: Not Provided

Test Setup Resources

Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Excel | Pdf

Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.

Normal Reports | Abnormal Reports

SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.

SI Normal Reports | SI Abnormal Reports

Test Update Resources

Change Type Effective Date
Test Changes - Referral Fee 2023-11-01