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COVID-19 Antibody Testing Update: Elitza Theel, Ph.D. - Insights

Elitza Theel, Ph.D., director of Mayo Clinic's Infectious Diseases Serology Laboratory, joins this episode of the "Answers From the Lab" podcast. Dr. Theel and Bobbi Pritt, M.D., discuss advances in antibody testing for COVID-19, why this...

Paraffin-embedded tissue testing for COVID-19: Anja Roden, M.D. - Insights

Anja Roden, M.D., a medical director for Mayo Clinic's Immunohistochemistry Laboratory, joins this episode of the "Answers From the Lab" podcast. Dr. Roden and Bobbi Pritt, M.D., discuss the development and evaluation of...

Ingenuity, collaboration, and expertise create a game-changing COVID-19 test swab - Insights

A massive effort culminated in Mayo Clinic designing, testing and mass-manufacturing a 3D-printed mid-turbinate swab for COVID-19 testing.

Next-generation sequencing: Examining an often oversimplified & misunderstood technology--Part I

In the last decade, genetic testing has evolved from single-gene Sanger based assays to much more complex next-generation sequencing (NGS) based assays.

Updated Test Promises Fewer False Positives in Newborn Screening for Krabbe Disease - Insights

Mayo Clinic’s Biochemical Genetics Laboratory has announced an updated second-tier test to detect Krabbe disease (KD) that uses psychosine (PSY) as a disease marker. The new test method has significantly higher sensitivity to detect this...

Next-generation sequencing: Examining an often oversimplified & misunderstood technology-Part II - Insights

One of the biggest misunderstandings about genetic testing is a perception that once a variant is identified and analyzed thoroughly, using all the best tools available, it can be associated with a specific disease or condition. But many...

Dendritic Cell Enumeration Test: Amir Sadighi Akha, M.D., D.Phil. - Insights

Amir Sadighi Akha, M.D., D.Phil., lab section director for Mayo Clinic's Cellular and Molecular Immunology Laboratory, joins this episode of the "Answers From the Lab" podcast. Dr. Sadighi Akha and Bobbi Pritt, M.D., discuss dendritic cell...

Second-Tier Assay for MPS I Newborn Screening Shows Remarkable Reduction of False Positives - Insights

Mucopolysaccharidosis type I (MPS I) is a rare genetic disorder that typically presents with progressive multisystem involvement in early childhood. This condition results from the deficiency of the enzyme, alpha-L-iduronidase (IDUA), which...

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New High-Resolution Targeted Opioid Screen: Superior Sensitivity and Specificity to Evaluate Adherence to Prescribed Opioid Therapy - Insights

In this month’s “Hot Topic,” Paul Jannetto, Ph.D., discusses the high-resolution targeted opioid screening test from Mayo Clinic Laboratories, which offers sensitivity and specificity for use in the monitoring and management of patients who...