The prescription and OTC drug screens are available to test for a broad spectrum of drugs in serum and urine. Testing is performed by GC/MS. When drugs are identified above the reportable (detection) limits in the specimen, they will be reported as "Present."
Note: Alcohol, LSD, digoxin, lithium, tetrahydrocannabinol (THC), and some benzodiazepines, opiates, amphetamine-type stimulants, and most drugs of abuse are not detected by this procedure. For these drugs, the specific confirmation tests should be ordered.
Last Updated November 2017 / Reviewed March 2022
The limits of detections (LODs) listed below reflect the concentrations at which the specific drugs can be reliably detected.
If the drug is detected at a level below the listed LOD, it will be reported only if it meets laboratory quality criteria for identification.
Drugs other than those listed below may be detected by GC-MS library matching and will be reported if they meet laboratory quality criteria for identification.
Note: Submission of less than the minimum sample volume requires increasing the limit of detection.
| Drug | Aliases | LOD (mcg/mL) | Approximate upper Therapeutic Level in serum (mcg/mL) | Notes |
|---|---|---|---|---|
| Acetaminophen | Tylenol | 10.00 | 30.00 | |
| Amitriptyline | Vanatrip, Elavil, | 1.00 | 0.20 | |
| Amobarbital | Amytal | 0.50 | 5.00 | Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation |
| Brompheniramine | Dimetapp, Lodrane | 0.50 | 0.015 | |
| Bupropion | Wellbutrin, Zyban | 1.00 | 0.10 | |
| Butabarbital | Butisol | 0.50 | 25.00 | Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation |
| Butalbital | 1.00 | 10.00 | Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation | |
| Caffeine | 1.50 | 20.00 | ||
| Carbamazepine | TEGretol, | 2.00 | 12.00 | |
| Carisoprodol | Soma, Vanadom | 1.00 | 4.00 | |
| Chlorpheniramine | 0.50 | 0.01 | ||
| Chlorpromazine | Thorazine | 1.00 | 0.30 | |
| Citalopram | CeleXA | 0.50 | 0.11 | |
| Clomipramine | Anafranil | 0.30 | 0.50 | |
| Clozapine | Clozaril | 0.50 | 0.35 | |
| Codeine | 1.00 | 0.20 | Preferred test for detection of opiates is a specific request; see Specific Drug Group Confirmation | |
| Cyclobenzaprine | Flexeril | 0.50 | 0.03 | |
| Desipramine | Norpramin | 1.00 | 0.30 | |
| Dextromethorphan | Robitussin, Benylin, VICKS 44 | 1.00 | 0.006 | |
| Diazepam | Valium | 0.25 | 2.50 | Preferred test for detection of benzodiazepines is a specific request; see Specific Drug Group Confirmation |
| Diphenhydramine | Benadryl, Nytol | 0.50 | 1.00 | |
| Doxepin | SINEquan, Zonalon | 0.50 | 0.15 | |
| Doxylamine | Unisom | 1.00 | 0.20 | |
| Fentanyl | Duragesic, Actiq, Sublimaze | 0.50 | 0.011 | Preferred test for detection of opioids is a specific request; see Specific Drug Group Confirmation |
| Fluoxetine | PROzac | 2.00 | 0.30 | |
| Guaifenesin | Mucinex, Robitussin | 1.00 | 1.50 | |
| Ibuprofen | Advil, Motrin | 2.50 | 50.00 | |
| Imipramine | Tofranil | 0.50 | 0.30 | |
| Lamotrigine | LaMICtal | 4.00 | 15.00 | |
| Levetiracetam | Keppra | 5.00 | 46.00 | |
| Lidocaine | 1.00 | 5.00 | ||
| Meperidine | Demerol | 1.00 | 0.70 | |
| Mephobarbital | 1.00 | 7.00 | Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation | |
| Meprobamate | Miltown, Trancot | 1.00 | 30.00 | |
| Metaxalone | Skelaxin | 0.50 | 2.00 | |
| Methadone | Dolophine | 0.50 | 1.00 | Preferred test for detection of opioids is a specific request; see Specific Drug Group Confirmation |
| Methsuximide | Celontin | 0.50 | 0.04 | |
| Methylphenidate | Concerta, Ritalin | 1.00 | 0.02 | |
| Midazolam | Versed | 0.50 | 0.60 | |
| Mirtazapine | Remeron | 0.20 | 0.04 | |
| Naproxen | Naprosyn, Aleve | 10.00 | 90.00 | |
| Nordiazepam | Nordazepam, Nordaz, Stilny, Madar, Vegesan | 0.50 | 2.50 | Preferred test for detection of benzodiazepines is a specific request; see Specific Drug Group Confirmation |
| Nortriptyline | Aventyl, Pamelor | 0.50 | 0.17 | |
| Oxcarbazepine Metabolite | 10-Hydroxy-10,11-Dihydrocarbamazepine, Trileptal, 10-monohydroxy metabolite (MHD) | 6.00 | ||
| Pentobarbital | Nembutal | 0.50 | 10.00 | |
| Phenobarbital | Luminal | 0.50 | 40.00 | Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation |
| Phenytoin | Dilantin | 2.50 | 2.00 | |
| Primidone | Mysoline | 2.50 | 12.00 | |
| Promethazine | Phenergan | 0.50 | 0.15 | |
| Salicylate | Aspirin | 50.00 | 300.00 | Variability in the LOD, not reliable detected in urine. |
| Secobarbital | Seconal | 0.50 | 2.00 | Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation |
| Sertraline | Zoloft | 0.50 | 0.20 | |
| Strychnine | 0.50 | |||
| Topiramate | Topamax | 2.00 | 20.00 | |
| Tramadol | Ultram | 0.50 | 0.80 | Preferred test for detection of opioids is a specific request; see Specific Drug Group Confirmation |
| Trazodone | Desyrel | 4.00 | 1.60 | |
| Trimipramine | Surmontil | 0.50 | 0.30 | |
| Valproic Acid | Depakene,Depakote, Depacon, Divalproex | 50.00 | 125.00 | Exhibits variable recovery in urine. |
| Venlafaxine | Effexor | 0.40 | 0.40 | |
| Zaleplon | Sonata | 1.00 | 49.00 | |
| Zolpidem | Ambien | 0.50 | 0.25 |