Test Id : HAEV0
Hemolytic Anemia Summary Interpretation
Useful For
Suggests clinical disorders or settings where the test may be helpful
Incorporating and summarizing subsequent results into an overall interpretation for the HAEV1 / Hemolytic Anemia Evaluation, Blood
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
When 1 or more molecular tests are added to the HAEV1 / Hemolytic Anemia Evaluation, Blood, then this test is also added as consultative interpretation that summarizes the testing performed as well as any pertinent clinical information. This summary is in addition to interpretations that may be provided for each component. This will be provided after additional testing is complete in order to incorporate subsequent results into an overall evaluation.
Method Name
A short description of the method used to perform the test
Only orderable as a reflex. For more information see HAEV1 / Hemolytic Anemia Evaluation, Blood.
Medical Interpretation
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
When 1 or more molecular tests are added to the HAEV1 / Hemolytic Anemia Evaluation, Blood, then this test is also added as consultative interpretation that summarizes the testing performed as well as any pertinent clinical information. This summary is in addition to interpretations that may be provided for each component. This will be provided after additional testing is complete in order to incorporate subsequent results into an overall evaluation.
Specimen Type
Describes the specimen type validated for testing
Whole Blood EDTA
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole Blood EDTA | Refrigerated | ||
Useful For
Suggests clinical disorders or settings where the test may be helpful
Incorporating and summarizing subsequent results into an overall interpretation for the HAEV1 / Hemolytic Anemia Evaluation, Blood
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
When 1 or more molecular tests are added to the HAEV1 / Hemolytic Anemia Evaluation, Blood, then this test is also added as consultative interpretation that summarizes the testing performed as well as any pertinent clinical information. This summary is in addition to interpretations that may be provided for each component. This will be provided after additional testing is complete in order to incorporate subsequent results into an overall evaluation.
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
The evaluation of patients with hemolytic anemia can be very complex and involves incorporation of not only testing, but integration of clinical and peripheral blood findings. Nonimmune hemolytic anemia can be due to many causes, including abnormalities in the hemoglobin molecule, red blood cell (RBC) membrane/cytoskeleton, or RBC enzyme cascade. If the evaluation of nonimmune hemolytic anemia utilizes the reflex molecular tests, a summary interpretation will be added to summarize the genetic, protein, peripheral blood, and clinical findings (if provided) will be added. This is beneficial to the ordering provider.
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Only orderable as a reflex. For more information see HAEV1 / Hemolytic Anemia Evaluation, Blood.
An interpretation report will be provided.
Interpretation
Provides information to assist in interpretation of the test results
An interpretive report will be provided that summarizes all testing as well as any pertinent clinical information.
Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
No significant cautionary statements
Clinical Reference
Recommendations for in-depth reading of a clinical nature
1. Steiner LA, Gallagher PG. Erythrocyte disorders in the perinatal period. Semin Perinatol. 2007;31(4):254-261
2. Beutler E. Glucose-6-phosphate dehydrogenase deficiency and other enzyme abnormalities. In: Beutler E, Lichtman MA, Collar BS, Kipps TJ, eds. Hematology. 5th ed. McGraw-Hill Book Company; 1995:564-581
3. Hoyer JD, Hoffman DR. The thalassemia and hemoglobinopathy syndromes. In: McClatchey KD, ed. Clinical Laboratory Medicine. 2nd ed. Lippincott, Williams and Wilkin; 2002:866-895
4. King MJ, Garcon L, Hoyer JD, et al. International Council for Standardization in Haematology: ICSH guidelines for the laboratory diagnosis of nonimmune hereditary red cell membrane disorders. Int J Lab Hematol. 2015;37(3):304-325
5. Lux SE. Anatomy of the red cell membrane skeleton: unanswered questions. Blood. 2016;127(2):187-199 doi:10.1182/blood-2014-12-512772
6. Gallagher PG. Abnormalities of the erythrocyte membrane. Pediatr Clin North Am. 2013;60(6):1349-1362
7. Bianchi P, Fermo E, Vercellati C, et al. Diagnostic power of laboratory tests for hereditary spherocytosis: a comparison study in 150 patients grouped according to molecular and clinical characteristics. Haematologica. 2012;97(4):516-523
8. Glader B. Hereditary hemolytic anemias due to red blood cell enzyme disorders. In: Greer JP, Arber DA, Glader B, et al, eds. Wintrobe's Clinical Hematology. 13th ed. Wolters Kluwer/Lippincott, Williams and Wilkins; 2014:728
9. Kipp BR, Roellinger SE, Lundquist PA, Highsmith WE, Dawson DB. Development and clinical implementation of a combination deletion PCR and multiplex ligation-dependent probe amplification assay for detecting deletions involving the human alpha-globin gene cluster. J Mol Diagn. 2011;13(5):549-557 doi:10.1016/j.jmoldx.2011.04.001
10. Harteveld CL, Higgs DR. Alpha-thalassemia. Orphanet J Rare Dis. 2010;5:13
11. Thein SL. The molecular basis of beta-thalassemia. Cold Spring Harb Persepct Med. 2013;1;3(5):a011700
12. Hein MS, Oliveira JL, Swanson KC, et al. Large deletions involving the beta globin gene complex: genotype-phenotype correlation of 119 cases. Blood. 2015;126:3374
13. Gallagher PG. Diagnosis and management of rare congenital nonimmune hemolytic disease. Hematology Am Soc Hematol Educ Program. 2015;2015:392-399
14. Koralkova P, van Solinge WW, van Wijk R. Rare hereditary red blood cell enzymopathies associated with hemolytic anemia - pathophysiology, clinical aspects, and laboratory diagnosis. Int J Lab Hematol. 2014;36(3):388-397
Method Description
Describes how the test is performed and provides a method-specific reference
A hematopathologist evaluates all results from the testing performed, and a summary interpretation is provided.
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Monday through Friday
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
Performing Laboratory Location
Indicates the location of the laboratory that performs the test
Fees :
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their account representative. For assistance, contact Customer Service.
Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
Not Applicable
LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
| Test Id | Test Order Name | Order LOINC Value |
|---|---|---|
| HAEV0 | Hemolytic Anemia Summary Interp | 59466-3 |
| Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
|---|---|---|
| 608090 | Hemolytic Anemia Summary Interp | 14869-2 |
| 608115 | Reviewed By | 18771-6 |